Research and practice together: the NIDA clinical trials network
DOI:
https://doi.org/10.20882/adicciones.352Keywords:
drug abuse, treatment, clinical trials, buprenorphine, motivational interviewing, contingency management, disseminationAbstract
The National Drug Abuse Treatment Clinical Trials Network (CTN), funded by the U.S. National Institute on Drug Abuse, is a nationwide collaboration of 17 addiction research centers and 152 community treatment programs. Treatments found to be effective in prior research are tested in multisite clinical trials, with the regular staff and patients of ongoing addiction treatment programs, to determine how well they work when delivered in the context of community practice. In five years of operation, the CTN has launched 21 multisite studies, enrolling nearly 7,000 patients in randomized clinical trials, and the first findings are beginning to be published. This article describes the CTN and its 21 current protocols, plus five more planned for implementation in 2006. It is a unique collaboration of research scientist and community practitioners, designed to test evidence-based treatments in real-life programs, and then facilitate their broader dissemination into practice.References
Carroll, K.M., Ball, S.A., Nich, C., Martino, S., Frankforter, T.L., Farentinos, C., Kunkel, L.E., Mikulich-Gilbertson, S.K., Morgensten, J., Obert, J.L., Polcin, D., Snead, N., & Woody, G. (en prensa) Motivational interviewing to improve treatment engagement and outcome in individuals seeking treatment for substance abuse:
A multisite effectiveness study. Drug and Alcohol Dependence.
Feaster, D.J., Robbins, M.S., Horigan, V. & Szapocznik, J. (2004). Statistical issues in multisite effectiveness trials: The case of brief strategic family therapy for adolescent drug abuse treatment. Clinical Trials, I, 428-439.
Forman, R.F., Bovasso, G. & Woody, G. (2001). Staff beliefs about addiction treatment. Journal of Substance Abuse Treatment, 21, 1-9.
Forman, R.F., Svikis, D., Montoya, I.D. & Blaine, J. (2004). Selection of a substance use disorder diagnostic instrument by the National Drug Abuse Treatment Clinical Trials Network. Journal of Substance Abuse Treatment, 27, 1-8.
Ling, W., Amass, L., Shoptaw, S., Annon, J.J., Hillhouse, M., Babcock, D., Brigham, G., Harrer, J., Reid, M., Muir, J., Buchan, B.J., Orr, D., Woody, G.E., Krejci, J., Zeidonis, D.M. (2005). A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: Findings from the National Institute on
Drug Abuse Clinical Trials Network. Addiction, 100, 1090-1100.
Miller, W.R., Zweben, J.E. & Johnson, W. (2005). Evidencebased
treatment. Why, what, where, when, and how? Journal of Substance Abuse Treatment, 29, 267-276.
Polcin, D. (2004). Bridging psychosocial research and treatment in community substance abuse programs. Addiction Research & Theory, 12, 275-283.
Whitten, L. (2005), CTN update: Blending initiative introduces two new training programs. NIDA notes 20 (1), 13.
