Cocaína prenatal y conducta materna en la emocionalidad y el consumo de cocaína en ratones adultos

Mª del Pilar Santacruz


Se analizaron los efectos de la cocaína 30mg/kg (s.c.) prenatal (gestación, día 1- 21) y de la conducta materna (madre biológica /nodriza) sobre la emocionalidad y el consumo voluntario de cocaína 30mg/kg, en ratones adultos. Después del parto cada madre crió cuatro hijos biológicos y adoptó cuatro (dos hembras y dos machos, en cada grupo). En la 5ª semana de edad, se evaluó la emocionalidad de los hijos tratados prenatalmente, seguido de la ingesta de cocaína (30mg/kg) siete días y nuevamente la emocionalidad. En la segunda evaluacion, las hembras, se mostraron más ansiosas, consumiendo mas agua y explorando menos. La cocaína (30 mg/kg) prenatal influyó más que las condiciones de crianza en la emocionalidad a mediano plazo en las hembras.

Palabras clave

cocaína; ratones; exposición prenatal; evaluación; grupo control

Texto completo:



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