Retraso en el acceso al primer tratamiento para la adicción en usuarios de opiáceos
DOI:
https://doi.org/10.20882/adicciones.1919Palabras clave:
Opiáceos, heroína, retraso en tratamiento, nuevos usuarios, adicción.Resumen
La búsqueda temprana de tratamiento para la adicción a los opiáceos se relaciona con un aumento de las posibilidades de éxito en el mismo. Los nuevos pacientes que buscan este tratamiento, y el tiempo que tardan en demandarlo, han sido escasamente descritos en España y Europa. El objetivo del presente estudio es identificar los factores individuales relacionados con el retraso en acudir por primera vez a tratamiento para la adicción a opiáceos. Se realizó un estudio transversal de consumidores de opiáceos admitidos por primera vez a tratamiento por adicción en centros públicos de la Comunidad de Madrid entre los años 2017-2019 (n = 366). Se estableció como variable dependiente el tiempo desde el inicio del consumo hasta el tratamiento (THT). Se realizó un análisis descriptivo general de los usuarios, seguido de un análisis bivariante tras dividir la muestra en dos grupos (THT < 5 años y THT ≥ 5 años). Para identificar aquellos factores asociados a un aumento en el THT se realizó un análisis de regresión logística multivariante. El perfil principal de la población de estudio fue: varón de mediana edad, español y desempleado que consume heroína por vía fumada. La mediana de THT fue: 9,27 años para varones y 4,75 para mujeres. Los factores que se asocian a un mayor THT fueron: > 49 años (OR: 5,87; IC95% 1,73-20,00), desempleo (OR: 2,54; IC95% 1,11-5,83), bajo nivel educativo (OR: 2,18; IC95% 1,04-4,59), no tener hogar (OR: 4,18; IC95% 1,29-13,57), primer consumo fuera del domicilio (OR: 2,54; IC95% 1,11-5,84) y VHC positivo (OR: 2,97; IC95% 1,00-8,82). El retraso en acudir a tratamiento se relaciona con los usuarios de más edad y menor nivel sociocultural. Las personas en riesgo de exclusión social deben priorizarse en las intervenciones para facilitar su acceso a los servicios de tratamiento.Citas
Bargagli, A. M., Faggiano, F., Amato, L., Salamina, G., Davoli, M., Mathis, F., Cuomo, L., Schifano, P., Burroni, P. & Perucci, C. A. (2006). VEdeTTE, a longitudinal study on effectiveness of treatments for heroin addiction in Italy: Study protocol and characteristics of study population. Substance Use & Misuse, 41(14), 1861-1879. https://doi.org/10.1080/10826080601025482.
Best, D. W., Day, E., Cantillano, V., Lopez Gaston, R., Nambamali, A., Sweeting, R. & Keaney,F. (2008). Mapping heroin careers: Utilising a standardised history-taking method to assess the speed of escalation of heroin using careers in a treatment-seeking cohort. Drug and Alcohol Review, 27(2), 165 - 170. https://doi.org/10.1080/09595230701829488.
Blanco, C., Iza, M., Rodríguez-Fernández, J. M., Baca-García, E., Wang, S. & Olfson, M. (2015). Probability and predictors of treatment-seeking for substance use disorders in the U.S. Drug and Alcohol Dependence, 149, 136-144. https://doi.org/10.1016/j.drugalcdep.2015.01.031.
Bonifonte, A. & Garcia, E. (2022). Improving geographic access to methadone clinics. Journal of Substance Abuse Treatment, 141, 108836. https://doi.org/10.1016/j.jsat.2022.108836.
Brugal, M. T., Domingo-Salvany, A., Puig, R., Barrio, G., García de Olalla, P. & de la Fuente, L. (2005). Evaluating the impact of methadone maintenance programmes on mortality due to overdose and aids in a cohort of heroin users in Spain. Addiction (Abingdon, England), 100(7), 981-989. https://doi.org/10.1111/j.1360-0443.2005.01089.x.
Cicero, T. J., Ellis, M. S., Surratt, H. L. & Kurtz, S. P. (2014). The changing face of heroin use in the United States: A retrospective analysis of the past 50 years. JAMA Psychiatry, 71(7), 821-826. https://doi.org/10.1001/jamapsychiatry.2014.366.
Darke, S. (2011). The Life of the Heroin User: Typical Beginnings, Trajectories and Outcomes. Cambridge University Press.
Day, C. A., Ross, J., Dietze, P. & Dolan, K. (2005). Initiation to heroin injecting among heroin users in Sydney, Australia: Cross sectional survey. Harm Reduction Journal, 2(1), 2. https://doi.org/10.1186/1477-7517-2-2.
de la Fuente de Hoz, L., Brugal Puig, M. T., Ballesta Gómez, R., Bravo Poetela, M. J., Barrio Anta, G., Domingo Salvany, A., Silva, T. & Ambrós, M. (2005). [Cohort study methodology of the ITINERE Project on heroin users in three Spanish cities and main characteristics of the participants]. Revista española de salud pública, 79(4), 475-491.
de la Fuente, L., Barrio, G., Vicente, J., Bravo, M. J. & Santacreu, J. (1995). The impact of drug-related deaths on mortality among young adults in Madrid. American Journal of Public Health, 85(1), 102-105. https://doi.org/10.2105/ajph.85.1.102.
de La Fuente, L., Bravo, M. J., Barrio, G., Parras, F., Suárez, M., Rodés, A. & Noguer, I. (2003). Lessons from the history of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic among Spanish drug injectors. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 37 Suppl 5, S410-415. https://doi.org/10.1086/377562.
de la Fuente, Luis, Brugal, M. T., Domingo-Salvany, A., Bravo, M. J., Neira-León, M. & Barrio, G. (2006). [More than thirty years of illicit drugs in Spain: A bitter story with some messages for the future]. Revista española de salud pública, 80(5), 505-520. https://doi.org/10.1590/s1135-57272006000500009.
Degenhardt, L., Bharat, C., Glantz, M. D., Sampson, N. A., Al-Hamzawi, A., Alonso, J., Andrade, L., Bunting, B., Cia, A., de Girolamo, G., de Jonge, P., Demyttenaere, K., Gureje, O., Haro, J. M., Harris, M., He, Y., Hinkov, H., Nasser, A., Karam, E.,… Kessler, R. C. (2019). Association of cohort and individual substance use with risk of transitioning to drug use, drug use disorder, and remission from disorder: Findings from the World Mental Health surveys. JAMA Psychiatry, 76(7), 708-720. https://doi.org/10.1001/jamapsychiatry.2019.0163.
Farhoudian, A., Razaghi, E., Hooshyari, Z., Noroozi, A., Pilevari, A., Mokri, A., Mohammadi, M. & Malekinejad, M. (2022). Barriers and facilitators to substance use disorder treatment: An overview of systematic reviews. Substance Abuse : Research and Treatment, 16, 11782218221118462. https://doi.org/10.1177/11782218221118462.
Flórez, G., López-Durán, A., Triñanes, Y., Osorio, J., Fraga, J., Fernández, J. M. & Arrojo, M. (2015). First-time admissions for opioid treatment: Cross-sectional and descriptive study of new opioid users seeking treatment. Neuropsychiatric Disease and Treatment, 11, 2431-2440. https://doi.org/10.2147/ndt.S84431.
González-Álvarez, S., Madoz-Gúrpide, A., Parro-Torres, C., Hernández-Huerta, D. & Ochoa Mangado, E. (2019). Relationship between alcohol consumption, whether linked to other substance use or not, and antiretroviral treatment adherence in HIV+ patients. Adicciones, 31(1), 8-17. https://doi.org/10.20882/adicciones.916.
Hall, N., Le, L., Majmudar, I., Teesson, M. & Mihalopoulos, C. (2021). Treatment-seeking behaviour among people with opioid use disorder in the high-income countries: A systematic review and meta-analysis. PloS One, 16(10), e0258620. https://doi.org/10.1371/journal.pone.0258620.
Hall, N. Y., Le, L., Majmudar, I. & Mihalopoulos, C. (2021). Barriers to accessing opioid substitution treatment for opioid use disorder: A systematic review from the client perspective. Drug and Alcohol Dependence, 221, 108651. https://doi.org/10.1016/j.drugalcdep.2021.108651.
Kessler, R. C., Aguilar-Gaxiola, S., Berglund, P. A., Caraveo-Anduaga, J. J., DeWit, D. J., Greenfield, S. F., Kolody, G., Olfson, M. & Vega, W. A. (2001). Patterns and predictors of treatment seeking after onset of a substance use disorder. Archives of General Psychiatry, 58(11), 1065-1071. https://doi.org/10.1001/archpsyc.58.11.1065.
Larance, B., Gisev, N., Cama, E., Nelson, E. C., Darke, S., Larney, S. & Degenhardt, L. (2018). Predictors of transitions across stages of heroin use and dependence prior to treatment-seeking among people in treatment for opioid dependence. Drug and Alcohol Dependence, 191, 145-151. https://doi.org/10.1016/j.drugalcdep.2018.03.056.
López-Pelayo, H., Aubin, H.-J., Drummond, C., Dom, G., Pascual, F., Rehm, J., Saitz, R., Scafato, E. & Gual, A. (2020). «The post-COVID era»: Challenges in the treatment of substance use disorder (SUD) after the pandemic. BMC Medicine, 18(1), 241. https://doi.org/10.1186/s12916-020-01693-9.
Marks, K. R. & Clark, C. D. (2018). The telescoping phenomenon: Origins in gender bias and implications for contemporary scientific inquiry. Substance Use & Misuse, 53(6), 901-909. https://doi.org/10.1080/10826084.2017.1385079.
Molist, G., Brugal, M. T., Barrio, G., Mesías, B., Bosque-Prous, M., Parés-Badell, O. & de la Fuente, L. (2018). Effect of ageing and time since first heroin and cocaine use on mortality from external and natural causes in a Spanish cohort of drug users. The International Journal on Drug Policy, 53, 8-16. https://doi.org/10.1016/j.drugpo.2017.11.011.
Mowbray, O., Perron, B. E., Bohnert, A. S. B., Krentzman, A. R. & Vaughn, M. G. (2010). Service use and barriers to care among heroin users: Results from a national survey. The American Journal of Drug and Alcohol Abuse, 36(6), 305-310. https://doi.org/10.3109/00952990.2010.503824.
Mur Sierra, A. & Ortigosa Gómez, S. (2014). [Is it possible a new heroin consumption epidemic in Spain?]. Medicina clínica, 143(9), 398-400. https://doi.org/10.1016/j.medcli.2014.06.004.
Observatorio Español de las Drogas y las Adicciones (2022). Informe 2022. Alcohol, tabaco y drogas ilegales en España. Madrid: Ministerio de Sanidad. Delegación del Gobierno para el Plan Nacional sobre Drogas.
Subdirección General de Adicciones (2017). Plan de Adicciones de la ciudad de Madrid 2017-2021. Ayuntamiento de Madrid. Madrid: Madrid Salud.
Puigdollers, E., Domingo-Salvany, A., Brugal, M. T., Torrens, M., Alvarós, J., Castillo, C., Magri, N., Martin, S. & Vázquez, J. M. (2004). Characteristics of heroin addicts entering methadone maintenance treatment: Quality of life and gender. Substance Use & Misuse, 39(9), 1353-1368. https://doi.org/10.1081/ja-120039392.
Ridenour, T. A., Maldonado-Molina, M., Compton, W. M., Spitznagel, E. L. & Cottler, L. B. (2005). Factors associated with the transition from abuse to dependence among substance abusers: Implications for a measure of addictive liability. Drug and Alcohol Dependence, 80(1), 1-14. https://doi.org/10.1016/j.drugalcdep.2005.02.005.
Roy, E., Haley, N., Leclerc, P., Cédras, L. & Boivin, J. F. (2002). Drug injection among street youth: The first time. Addiction (Abingdon, England), 97(8), 1003-1009. https://doi.org/10.1046/j.1360-0443.2002.00161.x.
Salazar, A., Moreno, S., De Sola, H., Moral-Munoz, J. A., Dueñas, M. & Failde, I. (2020). The evolution of opioid-related mortality and potential years of life lost in Spain from 2008 to 2017: Differences between Spain and the United States. Current Medical Research and Opinion, 36(2), 285-291. https://doi.org/10.1080/03007995.2019.1684251.
Sánchez-Carbonell, X. & Seus, L. (2000). Ten-year survival analysis of a cohort of heroin addicts in Catalonia: The EMETYST project. Addiction (Abingdon, England), 95(6), 941-948. https://doi.org/10.1046/j.1360-0443.2000.95694110.x.
Sánchez-Niubò, A., Fortiana, J., Barrio, G., Suelves, J. M., Correa, J. F. & Domingo-Salvany, A. (2009). Problematic heroin use incidence trends in Spain. Addiction (Abingdon, England), 104(2), 248-255. https://doi.org/10.1111/j.1360-0443.2008.02451.x.
Sanvisens, A., Rivas, I., Faure, E., Muñoz, T., Rubio, M., Fuster, D., Tor, J. & Muga, R. (2014). [Characteristics of heroin dependent patients admitted to a methadone treatment program]. Medicina clínica, 142(2), 53-58. https://doi.org/10.1016/j.medcli.2012.10.023.
Shand, F. L., Degenhardt, L., Slade, T. & Nelson, E. C. (2011). Sex differences amongst dependent heroin users: Histories, clinical characteristics and predictors of other substance dependence. Addictive behaviors, 36, 27-36. https://doi.org/10.1016/j.addbeh.2010.08.008.
Stoltman, J. J. K., Woodcock, E. A., Lister, J. J., Greenwald, M. K. & Lundahl, L. H. (2015). Exploration of the telescoping effect among not-in-treatment, intensive heroin-using research volunteers. Drug and Alcohol Dependence, 148, 217-220. https://doi.org/10.1016/j.drugalcdep.2015.01.010.
Torrens, M., Domingo-Salvany, A., Alonso, J., Castillo, C. & San, L. (1999). Methadone and quality of life. Lancet (London, England), 353(9158), 1101. https://doi.org/10.1016/S0140-6736(05)76462-X.
Torrens, M., Fonseca, F., Castillo, C. & Domingo-Salvany, A. (2013). Methadone maintenance treatment in Spain: The success of a harm reduction approach. Bulletin of the World Health Organization, 91(2), 136-141. https://doi.org/10.2471/BLT.12.111054.
Valencia, J., Alvaro-Meca, A., Troya, J., Cuevas, G., Gutiérrez, J., Morro, A., Alvarez, J., Pulido, L., Cañamares, I., Escobar, I., Moreno, S. & Ryan, P. (2019). High rates of early HCV reinfection after DAA treatment in people with recent drug use attended at mobile harm reduction units. The International Journal on Drug Policy, 72, 181-188. https://doi.org/10.1016/j.drugpo.2019.06.016.
Vallejo, F., Barrio, G., Brugal, M. T., Pulido, J., Toro, C., Sordo, L., Espelt, A. & Bravo, M. J. (2015). High hepatitis C virus prevalence and incidence in a community cohort of young heroin injectors in a context of extensive harm reduction programmes. Journal of Epidemiology and Community Health, 69(6), 599-603. https://doi.org/10.1136/jech-2014-205070.