Consumo de cannabis y alteraciones cognitivas en esquizofrenia y primeros episodios psicóticos

Leticia García Álvarez, Jesus J. Gomar, Mª Paz García-Portilla, Julio Bobes


Editorial del vol. 31, nº 2.

Palabras clave


Texto completo:

PDF PDF (English)


Asarnow, R. F., Nuechterlein, K. H., Subotnik, K. L., Fogelson, D. L., Torquato, R. D., Payne, D. L., . . . Guthrie, D. (2002). Neurocognitive impairments in nonpsychotic parents of children with schizophrenia and attentiondeficit/ hyperactivity disorder: the University of California, Los Angeles Family Study. Archives of General Psychiatry, 59, 1053-1060. doi:10.1001/archpsyc.59.11.1053.

Bahorik, A. L., Cornelius, J. R., Bangalore, S. S., Newhill, C. E., Keshavan, M. S. y Eack, S. M. (2014). Brief Report: The Impact of Alcohol and Cannabis Misuse on Cognition among Individuals with Schizophrenia. Schizophrenia Research: Cognition, 1, 160-163. doi:10.1016/j.scog.2014.08.001.

Barnes, T. R., Mutsatsa, S. H., Hutton, S. B., Watt, H. C. y Joyce, E. M. (2006). Comorbid substance use and age at onset of schizophrenia. British Journal of Psychiatry, 188, 237-242. doi:10.1192/bjp.bp.104.007237.

Block, R. I., O’Leary, D. S., Ehrhardt, J. C., Augustinack, J. C., Ghoneim, M. M., Arndt, S. y Hall, J. A. (2000). Effects of frequent marijuana use on brain tissue volume and composition. Neuroreport, 11, 491-496. doi:10.1097/00001756-200002280-00013.

Bugra, H., Studerus, E., Rapp, C., Tamagni, C., Aston, J., Borgwardt, S. y Riecher-Rossler, A. (2013). Cannabis use and cognitive functions in at-risk mental state and first episode psychosis. Psychopharmacology (Berl), 230, 299-308. doi:10.1007/s00213-013-3157-y.

Casajuana Kögel, C., López-Pelayo, H., Balcells-Olivero, M.M., Colom. J. y Gual A. (2018).  Psychoactive constituents of cannabis and their clinical implications: a systematic review. Adicciones, 30, 140-151. doi:10.20882/adicciones.858. 

Cunha, P. J., Rosa, P. G., Ayres Ade, M., Duran, F. L., Santos, L. C., Scazufca, M., . . . Schaufelberger, M. S. (2013). Cannabis use, cognition and brain structure in first-episode psychosis. Schizophrenia Research, 147, 209-215. doi:10.1016/j.schres.2013.04.009.

de la Serna, E., Mayoral, M., Baeza, I., Arango, C., Andres, P., Bombin, I., . . . Castro-Fornieles, J. (2010). Cognitive functioning in children and adolescents in their first episode of psychosis: differences between previous cannabis users and nonusers. The Journal of Nervous and Mental Disease, 198, 159-162. doi:10.1097/NMD.0b013e3181cc0d41.

DeRosse, P., Kaplan, A., Burdick, K. E., Lencz, T. y Malhotra, A. K. (2010). Cannabis use disorders in schizophrenia: effects on cognition and symptoms. Schizophrenia Research, 120, 95-100. doi:10.1016/j.schres.2010.04.007.

Elvevag, B. y Goldberg, T. E. (2000). Cognitive impairment in schizophrenia is the core of the disorder. Critical ReviewsTM in Neurobiology, 14, 1-21. doi:10.1615/CritRevNeurobiol.v14.i1.10.

Gage, S.H., Hickman, M. y Zammit, S. (2016). Association Between Cannabis and Psychosis: Epidemiologic Evidence. Biological Psychiatry, 79, 549-556. doi:10.1016/j.biopsych.2015.08.001.

Gonzalez-Pinto, A., Gonzalez-Ortega, I., Alberich, S., Ruiz de Azua, S., Bernardo, M., Bioque, M., . . . PEPs Group. (2016). Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History. Public Library of Science One, 11, e0160949. doi:10.1371/journal.pone.0160949.

Green, M. F., Kern, R. S. y Heaton, R. K. (2004). Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophrenia Research, 72, 41-51. doi:10.1016/j.schres.2004.09.009.

Hanna, R. C., Shalvoy, A., Cullum, C. M., Ivleva, E. I., Keshavan, M., Pearlson, G., . . . Ghose, S. (2016). Cognitive Function in Individuals With Psychosis: Moderation by Adolescent Cannabis Use. Schizophrenia Bulletin, 42, 1496-1503. doi:10.1093/schbul/sbw030.

Heaton, R. K., Gladsjo, J. A., Palmer, B. W., Kuck, J., Marcotte, T. D. y Jeste, D. V. (2001). Stability and course of neuropsychological deficits in schizophrenia. Archives of General Psychiatry, 58, 24-32. doi:10.1001/archpsyc.58.1.24.

Helle, S., Loberg, E. M., Gjestad, R., Schnakenberg Martin, A. M. y Lysaker, P. H. (2017). The positive link between executive function and lifetime cannabis use in schizophrenia is not explained by current levels of superior social cognition. Psychiatry Research, 250, 92-98. doi:10.1016/j.psychres.2017.01.047.

Jager, G., Van Hell, H. H., De Win, M. M., Kahn, R. S., Van Den Brink, W., Van Ree, J. M. y Ramsey, N. F. (2007). Effects of frequent cannabis use on hippocampal activity during an associative memory task. European Neuropsychopharmacology, 17, 289-297. doi:10.1016/j.euroneuro.2006.10.003.

Kern, R. S., Nuechterlein, K. H., Green, M. F., Baade, L. E., Fenton, W. S., Gold, J. M., . . . Marder, S. R. (2008). The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardization. The American Journal of Psychiatry, 165, 214-220. doi:10.1176/appi.ajp.2007.07010043.

Koskinen, J., Lohonen, J., Koponen, H., Isohanni, M. y Miettunen, J. (2010). Rate of cannabis use disorders in clinical samples of patients with schizophrenia: a meta-analysis. Schizophrenia Bulletin, 36, 1115-1130. doi:10.1093/schbul/sbp031.

Leeson, V. C., Harrison, I., Ron, M. A., Barnes, T. R. y Joyce, E. M. (2012). The effect of cannabis use and cognitive reserve on age at onset and psychosis outcomes in first-episode schizophrenia. Schizophrenia Bulletin, 38, 873-880. doi:10.1093/schbul/sbq153.

López Pelayo, H., de Miquel Montagut, L., Casajuana Kögel, C. y Balcells Oliveró, M. (2018). Post-truth Cannabis use: back to evidence-based medicine. Adicciones, 30, 237-242. doi:10.20882/adicciones.

Mallet, J., Ramoz, N., Le Strat, Y., Gorwood, P. y Dubertret, C. (2017). Heavy cannabis use prior psychosis in schizophrenia: clinical, cognitive and neurological evidences for a new endophenotype? European Archives of Psychiatry and Clinical Neuroscience, 267, 629-638. doi:10.1007/s00406-017-0767-0.

Martin-Santos, R., Fagundo, A. B., Crippa, J. A., Atakan, Z., Bhattacharyya, S., Allen, P., . . . McGuire, P. (2010). Neuroimaging in cannabis use: a systematic review of the literature. Psychological Medicine, 40, 383-398. doi:10.1017/S0033291709990729.

Meijer, J. H., Dekker, N., Koeter, M. W., Quee, P. J., van Beveren, N. J., Meijer, C. J., . . . Outcome of Psychosis, Investigators. (2012). Cannabis and cognitive performance in psychosis: a cross-sectional study in patients with non-affective psychotic illness and their unaffected siblings. Psychological Medicine, 42, 705-716. doi:10.1017/S0033291711001656.

Menendez-Miranda, I., García-Alvarez, L., García-Portilla, P., Gonzalez-Blanco, L., Saiz, P. y Bobes, J. (2019). History of lifetime cannabis use is associated with better cognition and worse real-world functioning in schizophrenia spectrum disorders. European Addiction Research, 25, 111-118. doi:10.1159/000497317. 

Moore, T. H., Zammit, S., Lingford-Hughes, A., Barnes, T. R., Jones, P. B., Burke, M. y Lewis, G. (2007). Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet, 370, 319-328. doi:10.1016/S0140-6736(07)61162-3.

Nuechterlein, K. H., Green, M. F., Kern, R. S., Baade, L. E., Barch, D. M., Cohen, J. D., . . . Marder, S. R. (2008). The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. The American Journal of Psychiatry, 165, 203-213. doi:10.1176/appi.ajp.2007.07010042.

Nunez, C., Ochoa, S., Huerta-Ramos, E., Banos, I., Barajas, A., Dolz, M., . . . Usall, J. (2016). Cannabis use and cognitive function in first episode psychosis: differential effect of heavy use. Psychopharmacology (Berl), 233, 809-821. doi:10.1007/s00213-015-4160-2.

Potvin, S., Stavro, K. y Pelletier, J. (2012). Paradoxical cognitive capacities in dual diagnosis schizophrenia: the quest for explanatory factors. Journal of Dual Diagnosis, 8, 35–47. doi:10.1080/15504263.2012.648549.

Power, B. D., Dragovic, M., Badcock, J. C., Morgan, V. A., Castle, D., Jablensky, A. y Stefanis, N. C. (2015). No additive effect of cannabis on cognition in schizophrenia. Schizophrenia Research, 168, 245-251. doi:10.1016/j.schres.2015.06.026.

Rabin, R. A., Barr, M. S., Goodman, M. S., Herman, Y., Zakzanis, K. K., Kish, S. J., . . . George, T. P. (2017). Effects of Extended Cannabis Abstinence on Cognitive Outcomes in Cannabis Dependent Patients with Schizophrenia vs Non-Psychiatric Controls. Neuropsychopharmacology, 42, 2259-2271. doi:10.1038/npp.2017.85.

Rabin, R. A., Zakzanis, K. K., Daskalakis, Z. J. y George, T. P. (2013). Effects of cannabis use status on cognitive function, in males with schizophrenia. Psychiatry Research, 206, 158-165. doi:10.1016/j.psychres.2012.11.019.

Ringen, P. A., Nesvag, R., Helle, S., Lagerberg, T. V., Lange, E. H., Loberg, E. M., . . . Melle, I. (2016). Premorbid cannabis use is associated with more symptoms and poorer functioning in schizophrenia spectrum disorder. Psychological Medicine, 46, 3127-3136. doi:10.1017/S0033291716001999.

Rodriguez-Sanchez, J. M., Ayesa-Arriola, R., Mata, I., Moreno-Calle, T., Perez-Iglesias, R., Gonzalez-Blanch, C., . . . Crespo-Facorro, B. (2010). Cannabis use and cognitive functioning in first-episode schizophrenia patients. Schizophrenia Research, 124, 142-151. doi:10.1016/j.schres.2010.08.017.

Sanchez-Torres, A. M., Basterra, V., Rosa, A., Fananas, L., Zarzuela, A., Ibanez, B., . . . Cuesta, M. J. (2013). Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings. European Archives of Psychiatry and Clinical Neuroscience, 263, 643-653. doi:10.1007/s00406-013-0404-5.

Schimmelmann, B.G., Conus, P., Cotton, S., Kupferschmid, S., McGorry, P.D. y Lambert, M. (2012). Prevalence and impact of cannabis use disorders in adolescents with early onset first episode psychosis. European Psychiatry, 27, 463–469. doi:10.1016/j.eurpsy.2011.03.001.

Schnakenberg Martin, A.M., Bonfils, K.A., Davis, B.J., Smith, E.A., Schuder, K. y Lysaker, P.H. (2016). Compared to high and low cannabis use, moderate use is associated with fewer cognitive deficits in psychosis. Schizophrenia Research: Cognition, 6, 15-21. doi:10.1016/j.scog.2016.09.001.

Schnell, T., Koethe, D., Daumann, J. y Gouzoulis-Mayfrank, E. (2009). The role of cannabis in cognitive functioning of patients with schizophrenia. Psychopharmacology (Berl), 205, 45-52. doi:10.1007/s00213-009-1512-9.

Setien-Suero, E., Martinez-Garcia, O., de la Foz, V. O., Vazquez-Bourgon, J., Correa-Ghisays, P., Ferro, A., . . . Ayesa-Arriola, R. (2018). Age of onset of Cannabis use and cognitive function in first-episode non-affective psychosis patients: Outcome at three-year follow-up. Schizophrenia Research, 201, 159-166. doi:10.1016/j.schres.2018.05.036.

van Os, J., Bak, M., Hanssen, M., Bijl, R. V., de Graaf, R. y Verdoux, H. (2002). Cannabis use and psychosis: a longitudinal population-based study. American Journal of Epidemiology, 156, 319-327. doi:10.1093/aje/kwf043. 

Waterreus, A., Badcock, J. C., Di Prinzio, P., Martin-Iverson, M. y Morgan, V. A. (2017). The impact of current cannabis use on general cognitive function in people with psychotic illness. Schizophrenia Research, 190, 164-171. doi:10.1016/j.schres.2017.03.038.

Yucel, M., Bora, E., Lubman, D. I., Solowij, N., Brewer, W. J., Cotton, S. M., . . . Pantelis, C. (2012). The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample. Schizophrenia Bulletin, 38, 316-330. doi:10.1093/schbul/sbq079.


Enlaces refback

  • No hay ningún enlace refback.