Bases bioquímicas y neurobiológicas de la adicción al alcohol

Autores/as

  • F. Javier Ayesta Enviar correspondencia a: Departamento de Fisiología y Farmacología, Facultad de Medicina, Universidad de Cantabria, C. Herrera Oria s/n, E-39011 SANTANDER

DOI:

https://doi.org/10.20882/adicciones.520

Palabras clave:

alcohol, receptor GABAA, receptor NMDA, tolerancia, síndrome de abstinencia, canales de calcio, reforzamiento, sistemas de recompensa

Resumen

Los últimos avances neurocientíficos han permitido profundizar en la fisiopatología del alcoholismo a nivel bioquímico y celular. Actualmente se sabe que los efectos agudos del etanol están fundamentalmente mediados por su interacción con neurotransmisores aminoácidos (primordialmente en los receptores GABAA y NMDA), así como cambios paralelos en determinadas aminas como la dopamina y la noradrenalina. Las respuestas neuroadpatativas en los receptores de aminoácidos subyacen probablemente en componentes importantes del síndrome de abstinencia, contribuyendo a la muerte neuronal que se encuentra en el alcoholismo crónico. Aunque no están tan bien comprendidas, las propiedades reforzadoras del etanol parecen estar mediadas fundamentalmente por la activación de receptores GABAA, la liberación de péptidos opioides, la interacción con receptores nicotínicos y la liberación indirecta de dopamina.

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Publicado

2002-12-15

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