Asociación diferencial entre el metabolismo regional de la corteza prefrontal y las estructuras límbicas y el tiempo de abstinencia en individuos dependientes de sustancias
Resumen
nivel del consumo de glucosa en un conjunto pre-establecido de regiones de interés y se llevaron a cabo correlaciones bivariadas entre el metabolismo de estas regiones y la duración de la abstinencia de los participantes. Se encontró una correlación negativa entre la duración de la abstinencia y el metabolismo regional de la amígdala y el hipocampo bilateralmente y una correlación positiva entre la duración de la abstinencia y la porción opercular del giro frontal inferior izquierdo. Las asociaciones encontradas sugieren la implicación diferencial de estas estructuras en el mantenimiento de la abstinencia y subrayan la necesidad de trabajar la regulación del estrés, el craving y el control de la conducta incluso tras importantes periodos de abstinencia.
Palabras clave
Texto completo:
PDFReferencias
Aron, A. R., Fletcher, P. C., Bullmore, E. T., Sahakian, B. J. y Robbins, T. W. (2003). Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans. Nature Neuroscience, 6, 115-116. doi: 10.1038/nn1003.
Aron, A. R., Monsell, S., Sahakian, B. J. y Robbins, T. W. (2004). A componential analysis of task-switching deficits associated with lesions of left and right frontal cortex. Brain, 127, 1561-1573. doi: 10.1093/brain/awh169.
Aron, A. R., Durston, S., Eagle, D. M., Logan, G. D., Stinear, C. M. y Stuphorn, V. (2007). Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognition. The Journal of Neuroscience, 27, 11860-11864. doi: 10.1523/jneurosci.3644-07.2007.
Barrós-Loscertales, A., Bustamante, J. C., Ventura-Campos, N., Llopis, J. J., Parcet, M. A. y Avila, C. (2011). Lower activation in the right frontoparietal network during a counting Stroop task in a cocaine- dependent group. Psychiatry research, 194, 111-118. doi: 10.1016/j.pscychresns.2011.05.001.
Belujon, P. y Grace, A. A. (2011). Hippocampus, amygdala, and stress: interacting systems that affect susceptibility to addiction. Annals of the New York Academy of Sciences, 1216, 114-121. doi: 10.1111/j.1749-6632.2010.05896.x.
Bjork, J. M., Momenan, R. y Hommer, D. W. (2009). Delay discounting correlates with proportional lateral frontal cortex volumes. Biological Psychiatry, 65, 710-713. doi:10.1016/j.biopsych.2008.11.023.
Brett, M., Anton, J-L., Valabregue, R. y Poline, J-B. (2002, junio). Region of interest analysis using an SPM toolbox. Comunicación presentada en la 8ª Conferencia Internacional de Human Brain Mapping, Japón.
Bustamante, J. C., Barrós-Loscertales, A., Costumero, V., Fuentes-Claramonte, P., Rosell-Negre, P., Ventura-Campos N,… Avila, C. (en prensa). Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients. Addiction Biology. doi:
1111/adb.12041.
Camí, J. y Farré, M. (2003). Drug addiction. The New England journal of medicine, 349, 975-986. doi: 10.1056/NEJMra023160.
Connolly, C. G., Foxe, J. J., Nierenberg, J., Shpaner, M. y Garavan, H. (2012). The neurobiology of cognitive control in successful cocaine abstinence. Drug and Alcohol Dependence, 121, 45-53. doi: 10.1016/j.drugalcdep.2011.08.007.
Claeys, J., Mertens, K., D’Asseler, Y. y Goethals, I. (2010). Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain. Annals of nuclear medicine, 24, 501-505. doi: 10.1007/s12149-010-0359-9.
Dagher, A., Tannenbaum, B., Hayashi, T., Pruessner, J. C. y McBride, D. (2009). An acute psychosocial stress enhances the neural response to smoking cues. Brain research, 1293, 40-48. doi: 10.1016/j.brainres.2009.07.048.
de Ruiter, M. B., Oosterlaan, J., Veltman, D. J., van den Brink, W. y Goudriaan, A. E. (2012). Similar hyporesponsiveness of the dorsomedial prefrontal cortex in problem gamblers and heavy smokers during an inhibitory control task. Drug and Alcohol Dependence, 121, 81-89. doi: 10.1016/j.drugalcdep.2011.08.010.
Figner, B., Knoch, D., Johnson, E. J., Krosch, A. R., Lisanby, S. H., Fehr, E. y Weber, E. U. (2010). Lateral prefrontal cortex and self-control in intertemporal choice. Nature Neuroscience, 13, 538-539. doi: 10.1038/nn.2516.
First, M. B., Spitzer, R. L., Gibbon, M., Williams, J. B. W. (1997). Structured Clinical Interview for DSM-IV Axis I disorders (SCID I). New York: Biometric Research Department.
Garavan, H., Kaufman, J. N. y Hester, R. (2008). Acute effects of cocaine on the neurobiology of cognitive control. Philosophical Transactions of the Royal Society of London. Series B. Biological Science, 363, 3267-3276. doi:
1098/rstb.2008.0106.
Garavan, H., Pankiewicz, J., Bloom, A., Cho, J. K., Sperry, L., Ross, T. J.,… Stein, E. A. (2000). Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. The American Journal of Psychiatry, 157, 1789-1798. doi: 10.1176/appi.ajp.157.11.1789.
Garavan, H. y Weierstall, K. (2012). The neurobiology of reward and cognitive control systems and their role in incentivizing health behavior. Preventive Medicine, 55, S17-23. doi: 10.1016/j.ypmed.2012.05.018.
García-Fuster, M. J., Flagel, S. B., Mahmood, S. T., Watson, S. J. y Akil, H. (2012). Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. PLoS One, 7, e42092. doi: 10.1371/journal.pone.0042092.
Goldman, M., Szucs-Reed, R. P., Jagannathan, K., Ehrman, R. N., Wang, Z., Li, Y.,… Franklin, T. R. (2013). Reward-related brain response and craving correlates of marijuana cue exposure: a preliminary study in
treatment-seeking marijuana-dependent subjects. Journal of Addiction Medicine, 7, 8-16. doi: 10.1097/adm.0b013e318273863a.
Goldstein, R. Z. y Volkow, N. D. (2011). Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nature Reviews. Neuroscience 12, 652-669. doi: 10.1038/nrn3119.
Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C.,… Margolin, A. (1996). Activation of memory circuits during cue-elicited cocaine craving.
Proceedings of the National Academy of Science of the United States of America, 93, 12040-12045. doi: 10.1073/pnas.93.21.12040.
McClure, S. M., Laibson, D. I., Loewenstein, G. y Cohen, J. D. (2004). Separate neural systems value immediate and delayed monetary rewards. Science, 306, 503-507. doi:10.1126/science.110090.
Moreno-López, L., Stamatakis, E. A., Fernández-Serrano, M. J., Gómez-Río, M., Rodríguez-Fernández, A., Pérez-García, M. y Verdejo-García A. (2012a). Neural correlates of hot and cold executive functions in polysubstance addiction: association between neuropsychological performance and resting brain metabolism as measured by positron emission tomography. Psychiatry Research, 203, 214-21. doi: 10.1016/j.pscychresns.2012.01.006.
Moreno-López, L., Stamatakis, E. A., Fernández-Serrano, M. J., Gómez-Río, M., Rodríguez-Fernández, A., Pérez-García, M. y Verdejo-García, A. (2012b). Neural correlates of the severity of cocaine, heroin, alcohol, MDMA and cannabis use in polysubstance abusers: a resting-PET brain metabolism study. PLoS One, 7, e39830.doi: 10.1371/journal.pone.0039830.
Moreno-López, L., Catena, A., Fernández-Serrano, M. J., Delgado-Rico, E., Stamatakis, E. A., Pérez-García, M. y Verdejo-García, A. (2012c). Trait impulsivity and prefrontal gray matter reductions in cocaine dependent individuals. Drug and Alcohol Dependence, 125, 208-214. doi: 10.1016/j.drugalcdep.2012.02.012.
Muraven, M. (2010). Practicing self-control lowers the risk of smoking lapse. Psychology of Addictive Behaviors, 24, 446-452. doi: 10.1037/a0018545.
Nestor, L. J., Ghahremani, D. G., Monterosso, J. y London, E. D. (2011). Prefrontal hypoactivation during cognitive control in early abstinent methamphetamine-dependent subjects. Psychiatry Research, 194, 287-295. doi:10.1016/j.pscychresns.2011.04.010.
Swick, D., Ashley, V. y Turken, A. U. (2008). Left inferior frontal gyrus is critical for response inhibition. BMC neuroscience, 9, 102. doi: 10.1186/1471-2202-9-102.
Tabibnia, G., Monterosso, J. R., Baicy, K., Aron, A. R., Poldrack, R. A., Chakrapani, S.,… London, E. D. (2011). Different forms of self-control share a neurocognitive substrate. Journal of Neuroscience, 31, 4805-4810. doi:10.1523/jneurosci.2859-10.2011.
Tapert, S. F., Schweinsburg, A. D., Drummond, S. P. A., Paulus, M. P., Brown, S. A., Yang, T. T. y Frank, L. R. (2007). Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology,
, 173-183. doi: 10.1007/s00213-007-0823-y.
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N.,… Joliot, M. (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI
MRI single-subject brain. NeuroImage, 15, 273-289. doi: 10.1006/nimg.2001.0978.
Verdejo-García, A. J., López-Torrecillas, F., Aguilar de Arcos, F. y Pérez-García, M. (2005). Differential effects of MDMA, cocaine, and cannabis use severity on distinctive components of the executive functions in polysubstance users: a multiple regression analysis. Addictive behaviors,
, 89-101. doi: 10.1016/j.addbeh.2004.04.015.
Volkow, N. D., Fowler, J. S., Wang, G. J. y Goldstein, R. Z. (2002). Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies. Neurobiology of Learning and Memory, 78, 610-624.
doi: 10.1006/nlme.2002.4099.
Volkow, N. D., Fowler, J. S., Wang, G. J., Telang, F., Logan, J., Jayne, M.,… Swanson, J. M. (2010). Cognitive control of drug craving inhibits brain reward regions in cocaine abusers. Neuroimage, 49, 2536-2543. doi: 10.1016/j.neuroimage.2009.10.088.
Volkow, N. D., Fowler, J. S. y Wang, G. J. (2003). The addicted human brain: insights from imaging studies. The Journal of Clinical Investigation, 111, 1444–1451 doi:10.1172/jci200318533.
Volkow, N. D. y Lee, T. K. (2004). Drug addiction: the neurobiology of behavior gone awry. Nature reviews. Neuroscience, 5, 963-970. doi: 10.1038/nrn1539.
Volkow, N. D., Tomasi, D., Wang, G.-J., Fowler, J. S., Telang, F.,… Wong, C. (2011). Reduced metabolism in brain “control networks” following cocaine-cues exposure in female cocaine abusers. PloS one, 6, e16573. doi:10.1371/journal.pone.0016573.
Vorel, S. R, Liu, X., Hayes, R. J., Spector, J. A. y Gardner, E.L. (2001). Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science, 292, 1175-1178. doi:10.1126/science.1058043.
Wise, R. A. (2009). Roles for nigrostriatal--not just mesocorticolimbic--
dopamine in reward and addiction. Trends in Neuroscience, 32, 517-524. doi: 10.1016/j.tins.2009.06.004.
Wrase, J., Makris, N., Braus, D. F., Mann, K., Smolka, M.N., Kennedy, D. N.,… Heinz, A. (2008). Amygdala volume associated with alcohol abuse relapse and craving. The American Journal of Psychiatry, 165, 1179-1184. doi:10.1176/appi.ajp.2008.07121877.
DOI: https://doi.org/10.20882/adicciones.43
Enlaces refback
- No hay ningún enlace refback.